Data-Analytics Modeling of Electrical Impedance Measurements for Cell Culture Monitoring

High-throughput data analysis challenges in laboratory automation and lab-on-a-chip devices’ applications are continuously increasing. In cell culture monitoring, specifically, the electrical cell-substrate impedance sensing technique (ECIS), has been extensively used for a wide variety of applications. One of the main drawbacks of ECIS is the need for implementing complex electrical models to decode the electrical performance of the full system composed by the electrodes, medium, and cells. In this work we present a new approach for the analysis of data and the prediction of a specific biological parameter, the fill-factor of a cell culture, based on a polynomial regression, data-analytic model. The method was successfully applied to a specific ECIS circuit and two different cell cultures, N2A (a mouse neuroblastoma cell line) and myoblasts. The data-analytic modeling approach can be used in the decoding of electrical impedance measurements of different cell lines, provided a representative volume of data from the cell culture growth is available, sorting out the difficulties traditionally found in the implementation of electrical models. This can be of particular importance for the design of control algorithms for cell cultures in tissue engineering protocols, and labs-on-a-chip and wearable devices applicationsEspaña, Ministerio de Ciencia e Innovación y Universidades project RTI2018-093512-B-C2

Una tecnología punta para estudiar fluidos volcánicos

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Optical Supersymmetry in the Time Domain

Originally emerged within the context of string and quantum field theory, and later fruitfully extrapolated to photonics, the algebraic transformations of quantum-mechanical supersymmetry were conceived in the space realm. Here, we introduce a paradigm shift, demonstrating that Maxwell's equations also possess an underlying supersymmetry in the time domain. As a result, we obtain a simple analytic relation between the scattering coefficients of a large variety of time-varying optical systems and uncover a wide new class of reflectionless, three dimensional, all-dielectric, isotropic, omnidirectional, polarization-independent, non-complex media. Temporal supersymmetry is also shown to arise in dispersive media supporting temporal bound states, which allows engineering their momentum spectra and dispersive properties. These unprecedented features define a promising design platform for free-space and integrated photonics, enabling the creation of a number of novel reconfigurable reflectionless devices, such as frequency-selective, polarization-independent and omnidirectional invisible materials, compact frequency-independent phase shifters, broadband isolators, and versatile pulse-shape transformers